A Fast And Simple Method For Preparation Of Copper Complexes From Schiff’s Base


Chemists often perform reactions with a mixture of substances, and preparing a mixture can be confusing.For example, if you’re acting like a chemist and have to prepare copper complexes from Schiff’s Base using a CuSO4 solution, this article does a first-rate job explaining the process step-by-step.

Introduction to Schiff’s Base

Schiff’s base is a fairly simple method for the preparation of copper complexes from aqueous solutions. The reaction takes place between copper(II) ions and a BASE salt, such as NaHCO 3 or KOH. Copper(II) ion displacement products are responsible for many of the activities of these salts, so it is important to select a BASE that will catalyze the desired reaction.

The reaction can be carried out in either organic or inorganic media, but both tend to favor the former. Suitable solvents include chloroform, methanol, and ethanol. In general, reactions proceeds faster in an acidic medium due to copper(II) ion speciation effects. Reactants should be kept tightly sealed during preparation in order to avoid oxidation and decomposition.

Preparation of Copper Complexes

Copper complexes can be prepared from Schiff’s base by treating the base with an organic acid. The organic acid reacts with the base to form a copper(II) complex. This complex can then be broken down by either hydrogen sulfide or oxidation to give the desired copper(I) complex. 

The reaction between Schiff’s base and an organic acid is reversible and thus multiple conversions can be made between different copper complexes. Some common organic acids that can be used in this reaction are Formate, Acetate, Benzoate, Phthalate and Citrate. The use of different organic acids will result in different copper complexes, as well as different colors of compounds.

Test Procedure

Schiff’s base is a very versatile and powerful organic synthesis method for preparing copper complexes. The following procedure details the steps necessary to prepare a Schiff’s base solution:

1. Begin by mixing together 2 equivalents of cupric acetate (II) salt and ethyl acetate in a beaker.

2. Add 10 ml of water, and stir well to combine.

3. Heat the mixture slowly to just below boiling point, and then carefully pour it into a conjugation flask. It will spurt out violently!

4. When the reaction has subsided, add 20 ml more ethyl acetate, and shake vigorously to combine.

5. Allow the solution to cool completely before pouring it into an ice bath.

6. Slowly add 50 ml of distilled water while freezing, and then let the mixture dissolve completely over night at -20 degrees Celsius.

7. Pour the slurry into pouring containers, leaving enough room at the top to allow for gradual evaporation during almost total refluxing in vacuo over about 4 hours (see Note 1). Carefully fractionalize the reaction product using basic nitric acid (HNO3), meta-chloroperbenzoic acid (CHCl3), or perchloric acid (HCl) according to standard conditions ([ ): ]) . 

   Note 1: This can be accomplished by allowing the reaction mixture to slowly drip from graduated cylinder onto a sheet


Copper complexes are powerful and valuable drugs that have numerous applications in modern pharmacology. However, preparing these compounds from Schiff’s base can be a time-consuming and complex process. In this article, I provide a fast and simple method for preparing copper complexes using Schiff’s base as the starting material. This method is easy to follow, producing high-quality results, so you can be confident that your products will meet desired standards. Thanks for reading!

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